Lipoxins are among a class of eicosanoids that are derived from arachidonate and known to be prevalent in airway tissues of asthmatics and other lung disease patients. This demonstrates that lipoxins are naturally occurring molecules and closely associated with eosinophil-related pathways. While their exact roles are not fully understood, both Lipoxin A4 (LXA4) and15-Epi-Lipoxin A4 (15-Epi-LXA4) have proven to be involved in anti-inflammatory responses. The LXA4, is however, not effective in abolishing allergen induced eotaxin while the analog 15-Epi-LXA4 has been shown to be effective. Furthermore, the 15-Epi-LXA4 has been established as an inhibitor of eosinophil localization in allergen sensitized tissue making it a molecule of great interest for tissue inflammation studies.
This ELISA kit was developed to be sensitive and selective for 15-Epi-LXA4 to provide the user a convenient means to study anti-inflammatory responses. The 15-Epi-LXA4 assay kit allows for quantitative results with the ease and convenience of a 96 well format. This assay is a competitive ELISA between enzyme conjugate and 15-Epi-LXA4 for a limited number of binding sites. Our specially designed extraction buffer eliminates the need for most urine and tissue culture supernatant to be extracted. Determination of 15-Epi-LXA4 levels may provide a greater understanding of the pathophysiology of inflammation and other disease.If using urine as a sample it is recommended to run our
in conjunction with your samples since urinary creatinine levels may be used to normalize the rate of excretion of other analytes.
Cross Reactivity15-epi-Lipoxin A4......................100.00%Lipoxin A4..........................................3%15 (R)- HETE...................................0.8%5(S)- HETE...................................<0.01%12(S)- HETE.................................<0.01%15(S)- HETE.................................<0.01% |
Oxford Biomedical Research
OBR公司开发,生产和销售检测试剂盒,重组蛋白和应用于生物医学和制药研究的抗体,现已具有400多种产品。
认识到减少疾病和改善人类健康将需要开发出更好的方法来识别和量化疾病的潜在危险因素,牛津生物医学研究(OBR)致力于为生物医学研究人员提供最佳的工具,用于分析氧化应激慢性炎症-两种最重要的危险因素,在多种人类疾病的发展中发挥关键作用,包括癌症,心血管疾病,糖尿病和神经变性。
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