A 75 kDa glucose regulated protein (GRP75) is a mitochondrial matrix protein that is generally recognized as a member of the heat shock protein 70 (HSP70) class of proteins. GRP75 is induced under conditions of low glucose and other nutritional and environmental stresses. Closely related proteins have been identified in the immune system (PBP74; CSA), liver (mtHSP70), and cell lines. GRP75 is involved in various chaperoning functions in protein translocation, folding, and function in mitochondria. It also appears to be involved in antigen recognition, cell proliferation, and senescence. Although primarily localized in mitochondria, related forms may be found in cytosol or on the surface of the extracellular membrane.This polyclonal antibody is specific for a peptide corresponding to a carboxy terminal fragment of human GRP75, and has been successfully used for immunoprecipitation, Western blotting, and immunohistochemical detection of GRP75 in human and rodent tissues. This antibody is selective for mature GRP75, and does not cross react with other HSP70 members.
References:1. Kim, et al., J. Immunol. 154:1614-1623, 1995.2. Wadhwa, Kaul, and Mitsui, Y. Cell Struct. Function, 19:1-10, 1994.3. Webster, et al., DNA and Cell Biol. 13:1213-1220, 1994.4. Mizzen, et al., J. Biol. Chem. 264:20664-20675, 1989 |
Oxford Biomedical Research
OBR公司开发,生产和销售检测试剂盒,重组蛋白和应用于生物医学和制药研究的抗体,现已具有400多种产品。
认识到减少疾病和改善人类健康将需要开发出更好的方法来识别和量化疾病的潜在危险因素,牛津生物医学研究(OBR)致力于为生物医学研究人员提供最佳的工具,用于分析氧化应激慢性炎症-两种最重要的危险因素,在多种人类疾病的发展中发挥关键作用,包括癌症,心血管疾病,糖尿病和神经变性。
产品列表:
没有。 | 品牌 | 货号 | 名称 | 规格 |
1 | 牛津生物医学研究 | IS20 | 1.0毫克 | |
2 | 牛津生物医学研究 | FR18 | 人血浆乳铁蛋白测定试剂盒 | 1套 |
3 | 牛津生物医学研究 | TA02 | 总抗氧化剂电源套件 | 1套 |
4 | 牛津生物医学研究 | PR32 | 抗兔CYP450 2E1 | 0.1毫升 |
5 | 牛津生物医学研究 | CE2B6.250 | 250毫克 | |
6 | 牛津生物医学研究 | GS70 | 0.1毫克 | |
7 | 牛津生物医学研究 | GS22 | 0.005毫克 | |
8 | 牛津生物医学研究 | PH91 | 100微克 | |
9 | 牛津生物医学研究 | PK50 | 面板 | |
10 | 牛津生物医学研究 | NS25 | 0.1毫克 | |
11 | 牛津生物医学研究 | UP33 | 0.05毫克 | |
12 | 牛津生物医学研究 | PK42 | 0.1毫克 | |
13 | 牛津生物医学研究 | PI66 | 1.0毫克 | |
14 | 牛津生物医学研究 | FS35 | 1套 | |
15 | 牛津生物医学研究 | MP12 | 0.001毫克 |